Case Study: Designing Cancer Drugs: Development of Gleevec

Many cancer chemotherapies have severe side effects because they are non-specific — they target all rapidly dividing cells, including normal cells in the gastrointestinal tract and hair follicles. Gleevec is extraordinarily effective because it was designed specifically to inhibit only the cancerous cells of a particular type of cancer, chronic myelogenous leukemia (CML), with few side

How was information about CML used to create this highly effective drug?

Why don’t we have designed drugs for all diseases?

Why is Gleevec so expensive?

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